Monkeypox: 4th case detected in India; know all about its causes, symptoms and treatment

India has reported four cases of monkeypox so far - three from Kerala and one from Delhi - the latest being that of a 34-year-old man in the national capital with no history of foreign travel testing positive for the disease.

The patient, who is presently recovering at an isolation centre at the Lok Nayak Hospital, had attended a 'stag party' in Himachal Pradesh's Manali recently, official sources said.

Q. What is monkeypox?

A. Monkeypox is a viral zoonosis (a virus transmitted to humans from animals) with symptoms similar to those seen in the past in smallpox patients, although it is clinically less severe.

There are two distinct genetic clades of the monkeypox virus - the Central African (Congo Basin) clade and West African. The Congo Basin clade has historically caused more severe disease and is thought to be more transmissible.

Q: What are the symptoms and what is the recovery period?


A: Monkeypox is usually a self-limited disease with the symptoms lasting two to four weeks. The case fatality ratio has historically ranged from zero to 11 per cent in the general population and has been higher among young children. In recent times, the case fatality ratio has been around three to six per cent.

Monkeypox typically presents itself with fever, headache, rashes for up to three weeks, sore throat, cough and swollen lymph nodes.

The symptoms include lesions, which usually begin within one to three days of the onset of fever, last for around two to four weeks, and are often described as painful until the healing phase when they turn itchy (in the crust stage).

A notable predilection for palm and soles is a characteristic of monkeypox.


Q. How does it spread?


A. Human-to-human transmission is known to occur primarily through large respiratory droplets generally requiring a prolonged close contact. It can also be transmitted through direct contact with body fluids or lesion material, and indirect contact with lesion material, such as through contaminated clothing or linens of an infected person.

Animal-to-human transmission may occur by bite or scratch of infected animals like small mammals, including rodents (rats, squirrels) and non-human primates (monkeys, apes) or through bush meat preparation.





Q: What is the incubation period and the period of communicability?



A: The incubation period (interval from infection to onset of symptoms) is usually six to 13 days but can range from five to 21 days. The period of communicability is one to two days before the rash until all the scabs fall off or get subsided.





Q: Is monkeypox sexually transmitted?



A: Tedros Adhanom Ghebreyesus, Director General of the World Health Organisation, while declaring monkeypox a public health emergency of international concern, said, "For the moment, this is an outbreak that's concentrated among men who have sex with men, especially those with multiple sexual partners. That means, this is an outbreak that can be stopped with the right strategies in the right groups."

A research published in the New England Journal of Medicine last Thursday, which looked at 528 confirmed infections, showed 95 per cent cases were transmitted through sexual activity and that 98 per cent of those infected were gay or bisexual men.





Q: Is monkeypox a new disease?



A: No. Human monkeypox was first identified in 1970 in the Democratic Republic of the Congo. Since then, most cases have been reported from rural, rainforest regions of the Congo Basin, particularly in the Democratic Republic of the Congo and human cases have increasingly been reported from across central and west Africa.

Since 1970, human cases of monkeypox have been reported in 11 African countries. In 2003, the first monkeypox outbreak outside Africa was in the US. This outbreak led to over 70 cases of monkeypox in America.

Monkeypox has also been reported in travelers from Nigeria to Israel and the United Kingdom in September 2018, December 2019, May 2021 and May 2022, to Singapore in May 2019, and to the US in November 2021.

In May this year, multiple cases of monkeypox were identified in several non-endemic countries. Globally, over 16,000 cases of monkeypox have now been reported from 75 countries and there have been five deaths so far due to the outbreak.

No need to be afraid, those infected stable now, says Kerala Health Minister

There is nothing to be concerned or worried about monkeypox as testing and surveillance have been intensified across the state and those among the primary contacts of the three infected persons in the state have tested negative, Kerala Health Minister Veena George said on Monday.

The minister said that while the World Health Organisation (WHO) has declared monkeypox outbreak as a global emergency due to its spread to around 68 countries across the world, the disease was not highly infectious and in Kerala the government was equipped to deal with it.

However, people, especially those with a foreign travel history, need to be cautious and alert, she said and added that the health professionals and workers in the state have been given training to identify and deal with monkeypox cases.

Directions have been issued to health authorities across the state to be vigilant, she said.

Regarding the three persons who tested positive for the disease, the minister said their health condition was stable and none among their primary contacts have tested positive for the infection till now.

A 35-year old man, who came to Kerala from the UAE earlier this month, has tested positive for monkeypox, making him the third case of the virus from the country as well as the state.

The Malappuram native had arrived in the southern state on July 6 and had fever since July 13, the health department had said.

India had last week reported a second confirmed case of monkeypox from Kerala's Kannur district.

The patient, a native of Kannur in north Kerala, had arrived in the southern state on July 13.

The first case of monkeypox, a rare but potentially serious viral illness, in the state as well as the country was reported from Kollam district of south Kerala on July 14.

Besides the three cases in Kerala, a 34-year-old man from Delhi with no history of foreign travel tested positive for monkeypox in the national capital, taking the country's tally of cases to four on Sunday.

According to WHO, monkeypox is a viral zoonosis (a virus transmitted to humans from animals), with symptoms similar to those seen in the past in smallpox patients, although it is clinically less severe.

With the eradication of smallpox in 1980 and subsequent cessation of smallpox vaccination, monkeypox has emerged as the most important orthopoxvirus for public health.